abstract：:Tumor vessel has been recognized as an important target for anticancer therapy. Cationic liposomes have been shown to selectively target tumor endothelial cells, thus can potentially be used as a carrier for chemotherapy agents. In this study, cationic liposomes containing 20 mol% cationic lipid dimethyl dioctadecyl a...

journal_title：International journal of pharmaceutics

authors： Wu J,Lee A,Lu Y,Lee RJ

更新日期：2007-06-07 00:00:00

abstract：:In this paper, we have used statistical experimental design to investigate the effect of several factors in coating process of lidocaine hydrochloride (LID) liposomes by a biodegradable polymer (chitosan, CH). These variables were the concentration of CH coating solution, the dripping rate of this solution on the lipo...

journal_title：International journal of pharmaceutics

authors： González-Rodríguez ML,Barros LB,Palma J,González-Rodríguez PL,Rabasco AM

更新日期：2007-06-07 00:00:00

abstract：:The objective of the present study was to investigate the biodistribution profiles of rizatriptan in the blood and brain of Wistar rats after peroral, subcutaneous, intranasal and intratracheal administration with a particular view to determining the applicability of inhalation delivery to achieve rapid and high avail...

journal_title：International journal of pharmaceutics

authors： Wang C,Quan LH,Guo Y,Liu CY,Liao YH

更新日期：2007-06-07 00:00:00

abstract：:Alginate-chitosan (ALG-CS) blend gel beads were prepared based on Ca2+ or dual crosslinking with various proportions of alginate and chitosan. The homogeneous solution of alginate and chitosan was dripped into the solution of calcium chloride; the resultant Ca2+ single crosslinked beads were dipped in the solution of ...

journal_title：International journal of pharmaceutics

authors： Xu Y,Zhan C,Fan L,Wang L,Zheng H

更新日期：2007-05-24 00:00:00

abstract：:To examine the relative contributions of molecular mobility and thermodynamic factor, the relationship between glass transition temperature (T(g)) and the crystallization rate was examined using amorphous dihydropyridines (nifedipine (NFD), m-nifedipine (m-NFD), nitrendipine (NTR) and nilvadipine (NLV)) with differing...

journal_title：International journal of pharmaceutics

authors： Miyazaki T,Yoshioka S,Aso Y,Kawanishi T

更新日期：2007-05-04 00:00:00

abstract：:Design of a pH sensitive alginate-guar gum hydrogel crosslinked with glutaraldehyde was done for the controlled delivery of protein drugs. Alginate is a non-toxic polysaccharide with favorable pH sensitive properties for intestinal delivery of protein drugs. Drug leaching during hydrogel preparation and rapid dissolut...

journal_title：International journal of pharmaceutics

authors： George M,Abraham TE

更新日期：2007-04-20 00:00:00

abstract：BACKGROUND:Pulmonary administration of the antimicrobial drugs colistin sulphomethate and tobramycin has been shown to be effective in slowing down pulmonary deterioration in cystic fibrosis (CF) patients. Both drugs are administered by liquid nebulisation, a technique known to have disadvantages. Dry powder inhalation...

journal_title：International journal of pharmaceutics

authors： Westerman EM,de Boer AH,Le Brun PPH,Touw DJ,Frijlink HW,Heijerman HGM

更新日期：2007-04-20 00:00:00

abstract：:The aim of this study is to compare microparticle uptake in animals of different ages, gender and species and at different time points. The 2mum latex/in vivo in situ model uses the observation of animal responses or post-mortem changes and also particle identification by fluorescence microscopy in nine sequential int...

journal_title：International journal of pharmaceutics

authors： Doyle-McCullough M,Smyth SH,Moyes SM,Carr KE

更新日期：2007-04-20 00:00:00

abstract：:The aim of this study was to provide preliminary validation of a new sublingual mucosal cell line (HO-1-u-1) for use as in vitro sublingual drug delivery screening of compounds involving passive diffusion. HO-1-u-1 cells were seeded on cell culture inserts. The ultrastructure and integrity of cell layers, inter-passag...

journal_title：International journal of pharmaceutics

authors： Wang Y,Zuo Z,Lee KK,Chow MS

更新日期：2007-04-04 00:00:00

abstract：PURPOSE:The purpose of this study is to characterize the surface activity of a water-soluble compound and its ability to form aggregates/micelles. METHODS:Aqueous solutions of the compound were prepared at various concentrations. Surface tension was determined using drop volume and Wilhelmy plate methods. Moreover, co...

journal_title：International journal of pharmaceutics

authors： Al-Maaieh A,Aburub A

更新日期：2007-04-04 00:00:00

abstract：:The effects of addition of divalent cations and phosphate buffer on the degree of beta-carotene encapsulation in a mannitol matrix during freeze-drying were analyzed. The degradation rate of encapsulated beta-carotene as a function of % RH and its relationship with the physical state of the matrix during storage at 25...

journal_title：International journal of pharmaceutics

authors： Sutter SC,Buera MP,Elizalde BE

更新日期：2007-03-06 00:00:00

abstract：:In this note we describe the substitution of the phospholipid component in classical ISCOMs (immune-stimulating complexes) with the cationic lipid dioleoyl-trimethyl-ammonium-propane (DOTAP). The self-assembled colloidal structures formed by DOTAP, Quil-A and cholesterol were characterised using transmission electron ...

journal_title：International journal of pharmaceutics

authors： Lendemans DG,Egert AM,Hook S,Rades T

更新日期：2007-03-06 00:00:00

abstract：:Release profiles of aspirin from hypromellose matrices in hydro-ethanolic media were studied. Percent aspirin released increased with increasing levels of ethanol in the dissolution media, correlating with the drug's solubility, however, dose dumping of aspirin did not occur. An initial rapid release was observed in m...

journal_title：International journal of pharmaceutics

authors： Roberts M,Cespi M,Ford JL,Dyas AM,Downing J,Martini LG,Crowley PJ

更新日期：2007-03-06 00:00:00

abstract：:Extrusion-spheronisation was used to generate smooth, highly spherical granules of a microcrystalline cellulose/propyl gallate/water paste. Freeze-drying retained the shape and size of the granules, whereas oven-drying produced roughened granules due to the uneven shrinkage of the wet powders. Compaction of one size f...

journal_title：International journal of pharmaceutics

authors： Song B,Rough SL,Wilson DI

更新日期：2007-03-06 00:00:00

abstract：:Meso-tetraphenyl porphine (mTPP) is a highly lipophilic, fluorescent porphyrin derivate and it is used as photosensitizer on the treatment of malign neoplasms. The aim of this study was to prepare mTPP loaded pluronic F127 and polyethylene glycol-distearoyl phosphatidylethanolamine (PEG(2000)-DSPE) micelles to evaluat...

journal_title：International journal of pharmaceutics

authors： Sezgin Z,Yuksel N,Baykara T

更新日期：2007-03-06 00:00:00

abstract：:Macromolecular crowding and the presence of organelles in the cytosol present barriers to particle mobility, such that it is unclear how nano-carriers can deliver their active agents to the nucleus. In this work a sixth generation amino terminated polyamide polylysine dendrimer (Gly-Lys(63) (NH(2))(64)) (MW 8149, diam...

journal_title：International journal of pharmaceutics

authors： Ruenraroengsak P,Al-Jamal KT,Hartell N,Braeckmans K,De Smedt SC,Florence AT

更新日期：2007-03-01 00:00:00

abstract：:Low density porous carriers are widely used in the pharmaceutical applications. Response surface methodology, using 3(2) factorial design was used to study drug adsorption on and its release patterns from microporous polypropylene (Accurel MP 1000) in the absence of additives. Ibuprofen, as model drug, was adsorbed on...

journal_title：International journal of pharmaceutics

authors： Sher P,Ingavle G,Ponrathnam S,Pawar AP

更新日期：2007-02-22 00:00:00

abstract：:The purpose of this study was to produce salbutamol sulfate (SS) as a model anti-asthmatic drug using high-gravity controlled precipitation (HGCP) through antisolvent crystallisation. An aqueous solution of SS was passed through a HGCP reactor with isopropanol as antisolvent to induce precipitation. Spray drying was e...

journal_title：International journal of pharmaceutics

authors： Chiou H,Li L,Hu T,Chan HK,Chen JF,Yun J

更新日期：2007-02-22 00:00:00

abstract：:Hydrophobic ([tetrakis(2,4-dimetil-3-pentyloxi)-phthalocyaninate]zinc(II)) (ZnPc) and hydrophilic ([tetrakis(N,N,N-trimethylammoniumetoxi)-phthalocyaninate]zinc(II) tetraiodide) (ZnPcMet) phthalocyanines were synthesized and loaded in ultradeformable liposomes (UDL) of soybean phosphatidylcholine and sodium cholate (6...

journal_title：International journal of pharmaceutics

authors： Montanari J,Perez AP,Di Salvo F,Diz V,Barnadas R,Dicelio L,Doctorovich F,Morilla MJ,Romero EL

更新日期：2007-02-07 00:00:00

abstract：:The effect of various surfactants (sodium cholate, sodium taurocholate, Tween 80 and Poloxamer F68) on enhancing the transepithelial permeability of fexofenadine.HCl was evaluated in a human nasal epithelial cell monolayer model. The cytotoxicity of the surfactants on the human nasal epithelial cells was evaluated by ...

journal_title：International journal of pharmaceutics

authors： Lin H,Gebhardt M,Bian S,Kwon KA,Shim CK,Chung SJ,Kim DD

更新日期：2007-02-07 00:00:00

abstract：UNLABELLED:The aim of this study is to validate the ability of the disappearance model to predict absorption rates of insulin aspart in pigs. The disappearance model is used as a screening tool to estimate absorption rates after subcutaneous injections in humans or pigs especially of insulin and insulin analogues. The ...

journal_title：International journal of pharmaceutics

authors： Sohoel A,Plum A,Frokjaer S,Thygesen P

更新日期：2007-02-07 00:00:00

abstract：:Porphyrin and their derivatives are being systematically studied as photosensitizers for photodynamic therapy. The ability to predict their membrane partition properties is of key importance to unveil their in vivo activity and applications. Several n-octanol/water partition coefficients (logP(OW)) of porphyrin deriva...

journal_title：International journal of pharmaceutics

authors： Engelmann FM,Rocha SV,Toma HE,Araki K,Baptista MS

更新日期：2007-02-01 00:00:00

abstract：:The purpose of this work was to investigate distribution, transition, bioadhesion and release behaviors of insulin loaded pH-sensitive nanoparticles in the gut of rats, as well as the effects of viscosity agent on them. Insulin was labeled with fluorescein isothiocyanate (FITC). The FITC-insulin solution and FITC-insu...

journal_title：International journal of pharmaceutics

authors： Li MG,Lu WL,Wang JC,Zhang X,Wang XQ,Zheng AP,Zhang Q

更新日期：2007-02-01 00:00:00

abstract：:Aggregation may compromise the stability as well as the biological activity of protein drugs. Detection of protein aggregates is needed in the process of protein characterization and during optimization of pharmaceutical formulations. This paper describes a technique, which consists of analysing protein aggregates by ...

journal_title：International journal of pharmaceutics

authors： Demeule B,Gurny R,Arvinte T

更新日期：2007-02-01 00:00:00

abstract：:The purpose of this study was to construct isotretinoin-loaded SLN (IT-SLN) formulation with skin targeting for topical delivery of isotretinoin. PRECIROL ATO 5 was selected as the lipid of SLN. Tween 80 and soybean lecithin were used as the surfactants to stabilize SLN. The hot homogenization method was performed to ...

journal_title：International journal of pharmaceutics

authors： Liu J,Hu W,Chen H,Ni Q,Xu H,Yang X

更新日期：2007-01-10 00:00:00

abstract：:A formulation of a eutectic mixture of lidocaine-prilocaine (EMLA) changes basal skin perfusion. Its use for alleviating pain associated with the Mantoux test may modify the recruitment of sensitised lymphocytes and then the response to tuberculin test. Twenty-four healthy BCG-vaccinated volunteers (26.7+/-4.1 years) ...

journal_title：International journal of pharmaceutics

authors： Dubus JC,Mely L,Lanteaume A

更新日期：2006-12-11 00:00:00

abstract：:In this paper, we report a new method based on supercritical carbon dioxide (scCO(2)) to fill and distribute the porous magnetic nanoparticles with n-octanol in a homogeneous manner. The high solubility of n-octanol in scCO(2) and high diffusivity and permeability of the fluid allow efficient delivery of n-octanol int...

journal_title：International journal of pharmaceutics

authors： Tsang SC,Yu CH,Gao X,Tam KY

更新日期：2006-12-11 00:00:00

abstract：:The aim of this study was to investigate the influence of the proteolytic enzyme bromelain on the permeation of heparin across the gastrointestinal epithelial barrier. Stability of the complex and effect of heparin on the enzymatic activity of bromelain was analysed photometrically by measuring bromelain enzymatic act...

journal_title：International journal of pharmaceutics

authors： Grabovac V,Bernkop-Schnürch A

更新日期：2006-12-01 00:00:00

abstract：:Core-shell type of nanoparticles (NPs) with manipulated degradation rate and balanced hydrophilic/hydrophobic properties were designed and characterized. The NPs based on the copolymers of n-butyl cyanoacrylate (BCA) and 2-octyl cyanoacrylate (OCA) were prepared by anion emulsion polymerization in 0.01N HCl solution w...

journal_title：International journal of pharmaceutics

authors： Huang CY,Lee YD

更新日期：2006-11-15 00:00:00

abstract：:Polysaccharide-coated liposomes have been studied for their potential use for peptide drug delivery by the oral route because they are able to minimize the disruptive influences on peptide drugs of gastrointestinal fluids. The aim of this work was to synthesize and characterize a modified polysaccharide, O-palmitoylsc...

journal_title：International journal of pharmaceutics

authors： Carafa M,Marianecci C,Annibaldi V,Di Stefano A,Sozio P,Santucci E

更新日期：2006-11-15 00:00:00

abstract：:The objective of this study was to identify key variables affecting the initial release (burst) and the encapsulation of leuprolide acetate-containing poly(lactide-co-glycolide) (PLGA) microparticles, which were prepared by the cosolvent evaporation method. Adjusting parameters, which affected the PLGA precipitation k...

journal_title：International journal of pharmaceutics

authors： Luan X,Skupin M,Siepmann J,Bodmeier R

更新日期：2006-11-06 00:00:00

abstract：:This paper describes the synthesis of capecitabine-loaded semi-interpenetrating network hydrogel microspheres of chitosan-poly(ethylene oxide-g-acrylamide) by emulsion crosslinking using glutaraldehyde. Poly(ethylene oxide) was grafted with polyacrylamide by free radical polymerization using ceric ammonium nitrate as ...

journal_title：International journal of pharmaceutics

authors： Agnihotri SA,Aminabhavi TM

更新日期：2006-11-06 00:00:00

abstract：:The overall aim of this study is to coat emulsion droplets with nanoparticles using a simple heterocoagulation process in aqueous dispersion and determine: the adsorption behavior and interfacial layer microstructure, droplet physical stability against flocculation and coalescence, and the release profile of a model l...

journal_title：International journal of pharmaceutics

authors： Prestidge CA,Simovic S

更新日期：2006-10-31 00:00:00

abstract：:Finasteride is indicated orally in the treatment of androgenetic alopecia and some other pilosebaceous unit (PSU) disorders. We wished to investigate whether topical application of finasteride-containing vesicles (liposomes and niosomes) could enhance drug concentration at the PSU, as compared to finasteride hydroalco...

journal_title：International journal of pharmaceutics

authors： Tabbakhian M,Tavakoli N,Jaafari MR,Daneshamouz S

更新日期：2006-10-12 00:00:00

abstract：:The aim of the present work was to characterize in vitro sumatriptan transdermal absorption through human skin and to investigate the effect of chemical enhancers and iontophoresis applied both individually and in combination. A secondary objective was to compare the results obtained with those in porcine skin under t...

journal_title：International journal of pharmaceutics

authors： Femenía-Font A,Balaguer-Fernández C,Merino V,López-Castellano A

更新日期：2006-10-12 00:00:00

abstract：:The aim of this work was to formulate a powder for inhalation with fusafungine, a drug substance initially highly cohesive. The classical approach based on micronization by jet milling to prepare respirable drug particles and then blending with a carrier was first applied. A fractional factorial experimental design wa...

journal_title：International journal of pharmaceutics

authors： Giry K,Péan JM,Giraud L,Marsas S,Rolland H,Wüthrich P

更新日期：2006-09-14 00:00:00

abstract：:Dissolution research started to develop about 100 years ago as a field of physical chemistry and since then important progress has been made. However, explicit interest in drug related dissolution has grown only since the realisation that dissolution is an important factor of drug bioavailability in the 1950s. This re...

journal_title：International journal of pharmaceutics

authors： Dokoumetzidis A,Macheras P

更新日期：2006-09-14 00:00:00

abstract：:The simultaneous skin permeation of drug and penetration enhancer have been studied in vitro. Simple formulations of mefenamic acid in PEG400 incorporating various proportions of ethanol or 1,8-cineole were prepared and applied to porcine ear skin in diffusion cells under infinite conditions. Receptor phases were assa...

journal_title：International journal of pharmaceutics

authors： Heard CM,Kung D,Thomas CP

更新日期：2006-09-14 00:00:00

abstract：:The purpose of the present work is to develop nanoparticles of a new antitubulin agent of the family of tripentones by means of a phase inversion process. Dynamic light scattering, transmission electron microscopy and zeta-potential measurements were used to characterize tripentone loaded nanoparticles. From interfaci...

journal_title：International journal of pharmaceutics

authors： Malzert-Fréon A,Vrignaud S,Saulnier P,Lisowski V,Benoît JP,Rault S

更新日期：2006-08-31 00:00:00

abstract：:Ethylene-vinyl acetate (EVA) is widely used as a membrane or matrix for transdermal drug delivery systems. In an attempt to determine the state of a drug in the EVA matrix, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and thermal analysis of the quinupramine-EVA matrix were carried out and ...

journal_title：International journal of pharmaceutics

authors： Cho CW,Choi JS,Shin SC

更新日期：2006-08-31 00:00:00